N,N ‘-Bisbenzylidenebenzene-1,4-diamines and N,N ‘-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors
2006; American Chemical Society; Volume: 49; Issue: 26 Linguagem: Inglês
10.1021/jm060566j
ISSN1520-4804
AutoresPäivi H. Kiviranta, Jukka Leppänen, Sergiy Kyrylenko, Heikki S. Salo, Maija Lahtela‐Kakkonen, Anu J. Tervo, Carsten Wittekindt, Tiina Suuronen, Erkki Kuusisto, Tomi Järvinen, Antero Salminen, Antti Poso, Erik A. A. Wallén,
Tópico(s)Toxin Mechanisms and Immunotoxins
ResumoA series of N,N'-bisbenzylidenebenzene-1,4-diamine and N,N'-bisbenzylidenenaphthalene-1,4-diamine derivatives were synthesized as inhibitors for human sirtuin type 2 (SIRT2). The design of the new compounds was based on two earlier reported hits from molecular modeling and virtual screening. The most potent compound was N,N'-bis(2-hydroxybenzylidene)benzene-1,4-diamine, which was equipotent with the most potent hit compound and well-known SIRT2 inhibitor sirtinol.
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