Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues
1983; Elsevier BV; Volume: 17; Issue: 3-4 Linguagem: Inglês
10.1016/0378-4274(83)90239-4
ISSN1879-3169
AutoresJ. Lüthy, T. Heim, Ch. Schlatter,
Tópico(s)Reproductive Health and Contraception
Resumo[3H]Retronecine and [3H]necic acid-labelled senecionine and seneciphylline were prepared biosynthetically with seedlings of Senecio vulgaris L. using [2,3-3H]putrescine and [4,5-3H]isoleucine, respectively, as precursors. Lactating rats dosed with these differently labelled pyrrolizidine alkaloids (PAs) excreted within 3 h approx. 0.08% of the applied radioactivity in the milk mainly as yet not identified water-soluble retronecine-derived metabolites and with approx. 0.02% as unchanged PAs. Highest tissue levels of PAs and metabolites, 6 h after administration, were found in liver and lungs.
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