Rate of natural disease progression in patients with chronic hepatitis C
2003; Elsevier BV; Volume: 38; Issue: 3 Linguagem: Inglês
10.1016/s0168-8278(02)00387-2
ISSN1600-0641
AutoresJean-Pierre Zarski, J. Mc Hutchison, Jean-Pierre Bronowicki, Nathalie Stürm, Richard Garcia‐Kennedy, Enkelejda Hodaj, Brenda Truta, Teresa L. Wright, Robert G. Gish,
Tópico(s)Hepatitis B Virus Studies
ResumoBackground/Aims: The interval at which liver biopsy should be repeated in untreated patients with chronic hepatitis C is not defined. We examined fibrosis change by METAVIR scoring in these patients in whom two or more liver biopsies were available.Methods: One hundred and eighty patients with histologically proven chronic hepatitis C were studied. Mean delay between biopsies was 3.67±2.69 years and 3.08±1.43 in the 16 patients having three biopsies. Univariate and multivariate analyses were performed to determine factors associated with liver fibrosis progression.Results: Median rate of fibrosis progression per year was 0.04 (0.00–0.55) to first biopsy, 0.00 (−0.84–1.02) between first and second biopsy (NS), and 0.17 (0.00–1.50) between second and third biopsy (P 40 years (OR=5) (2–12) and alcohol consumption of 1–50 g per day (OR=4) (2–12) and more than 50 g per day (OR=8) (3–23) were associated with severe fibrosis. The number of patients who increased in fibrosis stage was significantly higher after 4 years (P<0.02).Conclusions: An interval of at least 4–5 years is needed between liver biopsies to measure change in patients with mild liver disease.
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