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The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) “click” reaction and its applications. An overview

2011; Elsevier BV; Volume: 255; Issue: 23-24 Linguagem: Inglês

10.1016/j.ccr.2011.06.028

1873-3840

Liyuan Liang, Didier Astruc,

Advanced biosensing and bioanalysis techniques

A short overview of the copper(I)-catalyzed azide alkyne cycloaddition (CuAAC), the most used “click” reaction, is presented, including the introduction of the “click” concept, the conditions of copper(I) catalysis, the regioselectivity, the nature of the catalysts and ligands, mechanistic features, experimental conditions and applications to organic synthesis and organic materials.