Acridones as inducers of HL-60 cell differentiation
1999; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês
10.1016/s0145-2126(98)00174-x
ISSN1873-5835
AutoresSatoru Kawaii, Yasuhiko Tomono, Eriko Katase, Kazunori Ogawa, Masamichi Yano, Yuko Takemura, Motoharu Ju‐ichi, Chihiro Ito, Hiroshi Furukawa,
Tópico(s)Synthesis and biological activity
ResumoFifteen acridone alkaloids were examined for their activity of induction of human promyelocytic leukemia cell (HL-60) differentiation. HL-60 cells were differentiated into mature monocyte/macrophage by atalaphyllidine (9), atalaphyllinine (12), and des-N-methylnoracronycine (13). The activities of NBT reduction, nonspecific esterase, and phagocytosis, were induced by 2.5 μM of 9, 12, and 13. After a 4-day treatment, 9, 12, and 13 at 10 μM inhibited clonal proliferation of HL-60 cells by 28, 96, and 63%, respectively. The structure-activity relationship established from the results revealed that hydroxyl group at C-1 and prenyl group at C-2 had an important role.
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