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Local Ophthalmic Effects of Dipropylene Glycol Monomethyl Ether

1983; Informa; Volume: 2; Issue: 4-5 Linguagem: Inglês

10.3109/15569528309036263

1532-2505

Bryan Ballantyne,

Poisoning and overdose treatments

Rabbit eye irritation tests showed undiluted dipropylene glycol mono-methyl ether (DPGME) to cause moderately severe conjunctoblepharitis which began to resolve by 24 hr with no residual injury by 7 days. Minor keratitis occurred between the first and third days. DPGME (40%) caused mild conjunctival effects of 24 hr duration, and DPGME (20%) was without effect. Instillation of 0.1 ml caused peak increased intraocular tension at 10 min, ranging from 2% [DPGME (10%)] to 27% [DPGME (50%)]. DlPGME (40%) caused mean peak increases in intraocular tension, at 10 min, ranging from <1% (0.01 ml) to 22% (0.1 ml). Tensions returned to control values between 1 and 48 hr. Corneal thickness, measured in vivo, increased following instillation of 0.1 ml DPGME; peak increases at 30 min-1 hr ranged from 5% [DPGME (10%)] to 20% [DPIGME (80%)]. Using DPGME (40%), peak increases in corneal thickness at 30–60 min ranged from 3% (0.01 ml) to 30% (0.10 ml). Corneal thickness returned to control values between 1 and 48 hr potinstillation. Application of 0.04 ml of DPGME (20%) to human eyes caused mild transient sensory irritation and conjunctival inflammatory effects. with minor temporary increases in intraocular tension. DPGME may cause moderately severe conjunctoblepharitis, but the potential for corneal injury and functional damage to the eye is minimal.