The Paradox of Phencyclidine (PCP) Abuse
1979; American College of Physicians; Volume: 90; Issue: 3 Linguagem: Inglês
10.7326/0003-4819-90-3-428
ISSN1539-3704
Autores Tópico(s)Treatment of Major Depression
ResumoEditorials1 March 1979The Paradox of Phencyclidine (PCP) AbuseRICHARD STILLMAN, M.D., ROBERT C. PETERSEN, PH.D.RICHARD STILLMAN, M.D.Search for more papers by this author, ROBERT C. PETERSEN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-428 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhencyclidine, widely abbreviated as PCP, and known by street names such as "angel dust," "goon," and dozens of others, is a deeply disturbing drug, dangerous both in acute and chronic use. It has been said to be everything we were afraid marihuana would turn out to be but hasn't. Among abused drugs, it has no current rivals for a whole litany of disturbing effects: Accidental high doses can produce severe or fatal medical complications, acute and recurrent psychoses, suicidal depressions, and unpredictable violence. Chronic use brings aggressiveness, psychologic dependence, memory loss, and physiologic dependence. Tragically, its use is widespread among...References1. FAUMANFAUMAN MB: The psychiatric aspects of chronic phencyclidine use: a study of chronic PCP users, in Phencyclidine (PCP) Abuse: An Appraisal, edited by PETERSEN R, STILLMAN R. Washington, U.S. Government Printing Office, 1978 pp. 183-200 Google Scholar2. SIEGEL R: Phencyclidine and ketamine intoxication: a study of four populations of recreational users. See Reference 1, pp. 119-147 Google Scholar3. BURNSLERNER RS: Perspectives: acute phencyclidine intoxication. Clin Toxicol 9:477-501, 1976 CrossrefMedlineGoogle Scholar4. MARSELLAHICKS AR: Phenomenological aspects of phencyclidine abuse among ethnic groups in Hawaii. See Reference 1, pp. 201-209 Google Scholar5. POLLARDUHRSTERN JLE (ed): Drugs and Phantasy: The Effects of LSD, Psilocybin and Sernyl on College Students. Boston, Little, Brown and Co., 1965 Google Scholar6. RAINEYCROWDER JM: Prevalence of phencyclidine in street drug preparations. N Engl J Med 290:466-467, 1974 CrossrefMedlineGoogle Scholar7. KHANTZIANMCKENNA WG: Acute toxic and withdrawal reactions associated with drug use and abuse. Ann Intern Med 90:361-372, 1979 LinkGoogle Scholar8. YESAVAGEFREMAN JA: Acute phencyclidine intoxication: psychopathology and prognosis. J Clin Psychol 37:664-666, 1978 Google Scholar9. FAUMANFAUMAN MB: The differential diagnosis of organic based psychiatric disturbance in the emergency department. J Am Coll Emergency Physicians 6:315-323, 1977 CrossrefGoogle Scholar10. MELLO N: Control of drug administration: The role of aversive consequences. See Reference 1, pp. 289-308 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institute on Drug Abuse Rockville, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPhencyclidine-Based New Psychoactive SubstancesAcute neurotoxicology of drugs of abusePhencyclidine and Phencyclidine AnaloguesPhencyclidineA validated liquid chromatographic/tandem mass spectrometric method for the determination of phencyclidine in microliter samples of rat serumPhencyclidinePsychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 PolymorphismScreening for Drugs of Abuse (II): Cannabinoids, Lysergic Acid Diethylamide, Buprenorphine, Methadone, Barbiturates, Benzodiazepines and other DrugsPhencyclidine during Pregnancy: Behavioral and Neurochemical Effects in the OffspringSubchronic administration of MK-801 in the rat decreases cortical binding of [3H]d-AP5, suggesting down-regulation of the corticalN-methyl-d-aspartate receptorsDisinhibitory effect of phencyclidine in the hippocampus in vitro: PCP receptors implicatedMetabolic interactions of phencyclidine (PCP) and δ9-tetrahydrocannabinol (THC) in the ratMethysergide-induced precipitated withdrawal syndrome in phencyclidine-dependent ratsEffects of acute and chronic administrations of phencyclidine on the levels of serotonin and 5-hydroxyindoleacetic acid in discrete brain areas of mouseDrug and Alcohol AbuseAttenuation of pharmacological effects and increased metabolism of phencyclidine in morphine tolerant micePhencyclidine exposure and the developing mouse: Behavioral teratological implicationsThe Immediate Management of OverdoseDrug Abuse and DependenceBehavioral Teratology: A New Frontier in Neurobehavioral ResearchChronic phencyclidine increases methionine-enkephalin level in mouse striatumPhencyclidine: Its transfer across the placenta as well as into breast milkDevelopment of dispositional tolerance to phencyclidine by osmotic minipump in the mousePeculiarities of Phencyclidine Urinary Excretion and MonitoringUrinary Phencyclidine Excretion in Chronic AbusersEffect of chronic adminitration of phencyclidine on hepatic mixed-function oxidases in the mouseINTERACTION BETWEEN MORPHINE AND PHENCYCLIDINE: INTOXICATION AND CROSS-TOLERANCECharacteristics of Chronic Phencyclidine AbusersPhencyclidine: the new American street drug.Impaired glucose tolerance and diabetes--WHO criteria.Phencyclidine intoxicationChronic Phencyclidine (PCP) Abuse: A Psychiatric PerspectiveTolerance development to phencyclidine by chronic administrationOpioi analgesics and narcotic antagonists 1 March 1979Volume 90, Issue 3Page: 428-430KeywordsDrug abuseDrugsDustMemoryPhencyclidinePsychoses Issue Published: 1 March 1979 PDF DownloadLoading ...
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