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Me3SiCl/HMPA accelerated conjugate addition of catalytic copper reagent. Stereoselective synthesis of enol silyl ether of aldehyde

1986; Elsevier BV; Volume: 27; Issue: 34 Linguagem: Inglês

10.1016/s0040-4039(00)84901-1

1873-3581

Yoshiaki Horiguchi, Satoshi Matsuzawa, Eiichi Nakamura, Isao Kuwajima,

Asymmetric Hydrogenation and Catalysis

Copper-catalyzed conjugate addition of the Grignard reagents in the presence of Me3SiCl and HMPA proceeds in much higher yield than the reaction of conventional organocopper reagents and shows very good regio-, stereo-, and chemoselectivities.