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GABAB receptors make it to the top – as dimers

1999; Elsevier BV; Volume: 20; Issue: 3 Linguagem: Inglês

10.1016/s0165-6147(99)01323-1

1873-3735

H. Möhler, Jean‐Marc Fritschy,

Photoreceptor and optogenetics research

The GABAB receptor, the metabotropic receptor for the neurotransmitter γ-aminobutyric acid, was once termed the 'last wallflower on the receptors' dance' 1 Bowery N.G. Brown D.A. Nature. 1997; 386: 223-224 Crossref PubMed Scopus (40) Google Scholar , but lost this status when the GABABR1 receptor was cloned 2 Kaupmann K. et al. Nature. 1997; 386: 239-246 Crossref PubMed Scopus (873) Google Scholar , 3 Bettler B. Kaupmann K. Bowery N.G. Curr. Opin. Neurobiol. 1998; 8: 345-350 Crossref PubMed Scopus (140) Google Scholar . However, it was at the recent 4th International GABAB Symposium * 4th International GABAB Symposium, 5–7 November 1998, Los Angeles, USA. *4th International GABAB Symposium, 5–7 November 1998, Los Angeles, USA. that the GABAB receptor rose to stardom by revealing its partner, the GABABR2 receptor. In reporting that the GABAB receptor operates as a heterodimer, a new mechanism in signal transduction for G protein-coupled receptors was celebrated.