Normal Phase TLC Separation of Enantiomers Using Chiral Ion Interaction Agents
1990; Marcel Dekker; Volume: 13; Issue: 6 Linguagem: Inglês
10.1080/01483919008049236
ISSN2331-0413
AutoresJo Dee Duncan, Daniel W. Armstrong, Apryll M. Stalcup,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoAbstract A method for the thin layer chromatographic (TLC) separation of enantiomers and diastereomers involving the use of chiral ion interaction agents is described. Several aromatic amino alcohols were resolved by TLC on diol and/or high performance silica gel plates using a mobile phase containing (1R)-(-)- ammonium-10-camphorsulfonate or N-benzoxycarbonyl-glycyl-L-proline (ZGP). Many of these chiral aromatic amino alcohols are of pharmacological importance as α- and β-adrenergic blockers, adrenergic compounds, and anti-glaucoma agents. A comparison was made between various N-CBZ-amino acid derivatives as chiral counter ions/chiral mobile phase additives (CMAs). These separations could not be achieved on other normal phase TLC stationary phases including microcrystalline cellulose, alumina and ordinary silica gel plates.
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