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Quantitative analysis of the suppressors of cytokine signaling 1 and 3 in peripheral blood leukocytes of patients with multiple sclerosis

2014; Elsevier BV; Volume: 273; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2014.05.013

1872-8421

Virginia Sedeño-Monge, Raúl Arcega-Revilla, Emmanuel Rojas-Morales, Gerardo Santos‐López, Juan Carlos Pérez-García, Francisca Sosa-Jurado, Verónica Vallejo‐Ruiz, Casandra Lucrecia Solis-Morales, Salvador Aguilar-Rosas, Julio Reyes‐Leyva,

NF-κB Signaling Pathways

Multiple sclerosis (MS) is an autoimmune disease characterized by a triad of inflammation, demyelination and gliosis. Because the suppressors of cytokine signaling (Socs) regulate the immune response, we quantified SOCS1 and SOCS3 transcription in peripheral blood leukocytes of patients with MS. SOCS1 transcription decreased significantly in MS patients compared with neurologically healthy persons (0.08±0.02 vs. 1.02±0.23; p=0.0001); while SOCS3 transcription increased in MS patients compared with controls (2.76±0.66 vs. 1.03±0.27; p=0.0008). Our results showed an imbalance of SOCS1 and SOCS3 transcription in MS patients, and a moderated negative correlation between them (Spearman's r=-0.57; p=0.0003).