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Artigo Revisado por pares
BIBTEX RIS

β-Secretase (BACE) and GSK-3 mRNA levels in Alzheimer’s disease

2003; Elsevier BV; Volume: 116; Issue: 1-2 Linguagem: Inglês

10.1016/s0169-328x(03)00233-x

ISSN

1872-6941

Autores

Paul Preece, David Virley, Moheb Costandi, Robert Coombes, Stephen J. Moss, Anne W. Mudge, Elena Jazin, Nigel J. Cairns,

Tópico(s)

Cholinesterase and Neurodegenerative Diseases

Resumo

Beta-secretase (BACE) and glycogen synthase kinase (GSK 3) are two enzymes thought to play a role in Alzheimer's disease. We extracted mRNA from 90 Alzheimer and 81 control brains. Levels of mRNA were quantified for BACE and GSK 3 with TaqMan real-time RT-PCR. We found no change in the Alzheimer's disease brains relative to controls for either the BACE or the GSK 3alpha mRNA levels.

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