Alcohol Self-Administration Disrupts Reproductive Function in Female Macaque Monkeys
1983; American Association for the Advancement of Science; Volume: 221; Issue: 4611 Linguagem: Inglês
10.1126/science.6867739
ISSN1095-9203
AutoresNancy K. Mello, Mark P. Bree, Jack H. Mendelson, James Ellingboe, Norval W. King, Prabhat K. Sehgal,
Tópico(s)Neuroendocrine regulation and behavior
ResumoFemale macaque monkeys self-administered high doses of alcohol (2.9 to 4.4 grams per kilogram per day) for 3 to 6½ months. Amenorrhea, atrophy of the uterus, decreased ovarian mass, and significant depression of luteinizing hormone levels were associated with chronic alcohol intoxication. Reproductive system failure in female primates following self-induced dependence on alcohol parallels the results of clinical studies of alcoholic women.
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