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Allelic loss at 1p34, 13q12, 17p13.3, and 17q21.1 correlates with poor postoperative prognosis in breast cancer

1999; Wiley; Volume: 26; Issue: 2 Linguagem: Inglês

10.1002/(sici)1098-2264(199910)26

1098-2264

Mitsuru Emi, Masataka Yoshimoto, Takaaki Sato, Satoshi Matsumoto, Yoshihito Utada, Isao Ito, Kaori Minobe, Takuji Iwase, Toyomasa Katagiri, Kouichi Bando, Futoshi Akiyama, Yousuke Harada, Kouichi Fukino, Goi Sakamoto, Mieko Matsushima, Aritoshi Iida, Takashi Tada, Hiroko Saito, Yoshio Miki, Fujio Kasumi, Yusuke Nakamura,

Cancer-related Molecular Pathways

Genes, Chromosomes and CancerVolume 26, Issue 2 p. 134-141 Research Article Allelic loss at 1p34, 13q12, 17p13.3, and 17q21.1 correlates with poor postoperative prognosis in breast cancer† Mitsuru Emi, Mitsuru Emi Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorMasataka Yoshimoto, Masataka Yoshimoto Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorTakaaki Sato, Takaaki Sato Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorSatoshi Matsumoto, Satoshi Matsumoto Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorYoshihito Utada, Yoshihito Utada Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorIsao Ito, Isao Ito Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorKaori Minobe, Kaori Minobe Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorTakuji Iwase, Takuji Iwase Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorToyomasa Katagiri, Toyomasa Katagiri Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, JapanSearch for more papers by this authorKouichi Bando, Kouichi Bando Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorFutoshi Akiyama, Futoshi Akiyama Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorYousuke Harada, Yousuke Harada Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorKouichi Fukino, Kouichi Fukino Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorGoi Sakamoto, Goi Sakamoto Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorMieko Matsushima, Mieko Matsushima Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, JapanSearch for more papers by this authorAritoshi Iida, Aritoshi Iida Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorTakashi Tada, Takashi Tada Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorHiroko Saito, Hiroko Saito Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorYoshio Miki, Yoshio Miki Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorFujio Kasumi, Fujio Kasumi Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorYusuke Nakamura, Corresponding Author Yusuke Nakamura yusuke@ims.u-tokyo.ac.jp Department of Human Genome Analysis, Cancer Institute, Toshima-ku, Japan Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, JapanLaboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, 4–6-1, Shiroganedai, Minato-ku, Tokyo, 108–8639, Japan.Search for more papers by this author Mitsuru Emi, Mitsuru Emi Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorMasataka Yoshimoto, Masataka Yoshimoto Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorTakaaki Sato, Takaaki Sato Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorSatoshi Matsumoto, Satoshi Matsumoto Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorYoshihito Utada, Yoshihito Utada Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorIsao Ito, Isao Ito Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorKaori Minobe, Kaori Minobe Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorTakuji Iwase, Takuji Iwase Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorToyomasa Katagiri, Toyomasa Katagiri Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, JapanSearch for more papers by this authorKouichi Bando, Kouichi Bando Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorFutoshi Akiyama, Futoshi Akiyama Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorYousuke Harada, Yousuke Harada Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorKouichi Fukino, Kouichi Fukino Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorGoi Sakamoto, Goi Sakamoto Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorMieko Matsushima, Mieko Matsushima Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, JapanSearch for more papers by this authorAritoshi Iida, Aritoshi Iida Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, JapanSearch for more papers by this authorTakashi Tada, Takashi Tada Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorHiroko Saito, Hiroko Saito Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorYoshio Miki, Yoshio Miki Department of Human Genome Analysis, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorFujio Kasumi, Fujio Kasumi Department of Surgery and Pathology, Cancer Institute, Toshima-ku, JapanSearch for more papers by this authorYusuke Nakamura, Corresponding Author Yusuke Nakamura yusuke@ims.u-tokyo.ac.jp Department of Human Genome Analysis, Cancer Institute, Toshima-ku, Japan Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, JapanLaboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, 4–6-1, Shiroganedai, Minato-ku, Tokyo, 108–8639, Japan.Search for more papers by this author First published: 31 August 1999 https://doi.org/10.1002/(SICI)1098-2264(199910)26:2 3.0.CO;2-9Citations: 19 † M.E. and M.Y. contributed equally to this work. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Allelic losses of tumor suppressor genes (TSGs), or the chromosomal regions harboring them, in tumor DNA may become useful postoperative prognostic indicators. To examine whether specific allelic losses might correlate with postoperative survival in a 5-year prospective follow-up, we tested tumors from a cohort of 264 breast cancer patients for allelic losses of 18 microsatellite markers representing either a known TSG or a region where genetic alterations are frequent in breast tumors. Patients whose tumors had lost an allele at 1p34, 13q12, 17p13.3, or 17q21.1 had significantly higher risks of postoperative mortality than those whose tumors retained both alleles at those loci (at 1p34, a 5-year mortality rate of 29% among patients with losses vs. 7% with retentions, P = 0.0008; at 13q12, 31% vs. 10%, P = 0.0062; at 17p13.3, 24% vs. 13%, P = 0.026; and at 17q21.1, 31% vs. 13%, P = 0.0047). Furthermore, combined losses at 13q12 and 17p13.3 increased the predicted postoperative mortality risks by a factor of 9.6 (5-year mortality rate of 42% vs. 5% with retentions, P = 0.0001), and combined losses at 1p34 and 17p13.3 raised the predicted postoperative mortality risks by a factor of 8.6 (27% vs. 3%, P = 0.0064). We conclude that allelic losses at these loci can serve as negative prognostic indicators to guide postoperative management of patients. Genes Chromosomes Cancer 26:134–141, 1999. © 1999 Wiley-Liss, Inc. Citing Literature Volume26, Issue2October 1999Pages 134-141 RelatedInformation