Selenium status and allergic disease in a cohort of New Zealand children
2012; Wiley; Volume: 42; Issue: 4 Linguagem: Inglês
10.1111/j.1365-2222.2012.03924.x
ISSN1365-2222
AutoresC.D. Thomson, Kristin Wickens, Jody C Miller, Tristram Ingham, Philippa Lampshire, Michael Epton, G. Ian Town, Philip Pattemore, Julian Crane,
Tópico(s)Air Quality and Health Impacts
ResumoClinical & Experimental AllergyVolume 42, Issue 4 p. 560-567 Original Article Selenium status and allergic disease in a cohort of New Zealand children C. D. Thomson, Corresponding Author C. D. Thomson Department of Human Nutrition, University of Otago, Dunedin Correspondence: Professor Christine D. Thomson Department of Human Nutrition University of Otago PO Box 56 Dunedin 9054, New Zealand. E-mail: [email protected]Search for more papers by this authorK. Wickens, K. Wickens Department of Medicine, University of Otago Wellington School of Medicine and Health Sciences, WellingtonSearch for more papers by this authorJ. Miller, J. Miller Department of Human Nutrition, University of Otago, DunedinSearch for more papers by this authorT. Ingham, T. Ingham Department of Medicine, University of Otago Wellington School of Medicine and Health Sciences, WellingtonSearch for more papers by this authorP. Lampshire, P. Lampshire Department of Medicine, University of Otago Wellington School of Medicine and Health Sciences, WellingtonSearch for more papers by this authorM. J. Epton, M. J. Epton Department of Medicine, Christchurch School of Medicine and Health Sciences, ChristchurchSearch for more papers by this authorG. I. Town, G. I. Town Vice-Chancellor's Office, University of Canterbury, ChristchurchSearch for more papers by this authorP. Pattemore, P. Pattemore Department of Paediatrics, Christchurch School of Medicine and Health Sciences, Christchurch, New ZealandSearch for more papers by this authorJ. Crane, J. Crane Department of Medicine, University of Otago Wellington School of Medicine and Health Sciences, WellingtonSearch for more papers by this authorThe year six New Zealand Asthma and Allergy Cohort Study Group (NZAACS6), The year six New Zealand Asthma and Allergy Cohort Study Group (NZAACS6)Search for more papers by this author C. D. Thomson, Corresponding Author C. D. Thomson Department of Human Nutrition, University of Otago, Dunedin Correspondence: Professor Christine D. Thomson Department of Human Nutrition University of Otago PO Box 56 Dunedin 9054, New Zealand. E-mail: [email protected]Search for more papers by this authorK. Wickens, K. Wickens Department of Medicine, University of Otago Wellington School of Medicine and Health Sciences, WellingtonSearch for more papers by this authorJ. Miller, J. Miller Department of Human Nutrition, University of Otago, DunedinSearch for more papers by this authorT. Ingham, T. Ingham Department of Medicine, University of Otago Wellington School of Medicine and Health Sciences, WellingtonSearch for more papers by this authorP. Lampshire, P. Lampshire Department of Medicine, University of Otago Wellington School of Medicine and Health Sciences, WellingtonSearch for more papers by this authorM. J. Epton, M. J. Epton Department of Medicine, Christchurch School of Medicine and Health Sciences, ChristchurchSearch for more papers by this authorG. I. Town, G. I. Town Vice-Chancellor's Office, University of Canterbury, ChristchurchSearch for more papers by this authorP. Pattemore, P. Pattemore Department of Paediatrics, Christchurch School of Medicine and Health Sciences, Christchurch, New ZealandSearch for more papers by this authorJ. Crane, J. Crane Department of Medicine, University of Otago Wellington School of Medicine and Health Sciences, WellingtonSearch for more papers by this authorThe year six New Zealand Asthma and Allergy Cohort Study Group (NZAACS6), The year six New Zealand Asthma and Allergy Cohort Study Group (NZAACS6)Search for more papers by this author First published: 12 January 2012 https://doi.org/10.1111/j.1365-2222.2011.03924.xCitations: 14 Members of the year six New Zealand Asthma and Allergy Cohort Study Group (NZAACS6) are listed in the Appendix 1. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Summary Background New Zealand has one of the highest rates of asthma and atopy. Selenium has been implicated in the aetiology of asthma, and associations between low selenium status and asthma in New Zealand children have been reported. Objective The aim was to investigate the association between selenium status and allergic disease in a birth cohort of New Zealand children. Methods The New Zealand Asthma and Allergy Cohort Study is a prospective birth cohort in Wellington and Christchurch, involving 1105 infants born 1997–2001. During the 6-year assessment (n = 635), associations were investigated between plasma selenium (PlSe) and whole blood glutathione peroxidase activity (WBGPx) and allergy-related health outcomes including asthma, wheeze, hayfever, rhinitis, eczema and rash. Results Wellington children had greater PlSe and WBGPx than Christchurch children (P < 0.001 for both). PlSe (P = 0.004) and WBGPx (P = 0.03) were lower in children exposed to environmental smoke, but differences were no longer significant after adjustment for study location, current household smoking (5–6 years), maternal smoking during pregnancy, family history (either parent with asthma, eczema or hayfever), prioritized ethnicity (Maori, Pacific peoples, Other, European), gender, season born, number of siblings, New Zealand Deprivation Index and body mass index at 6 years. Analysis of PlSe or WBGPx as continuous variables or of quartiles of PlSe with health outcomes showed no significant associations after adjustment. Univariate analysis of quartiles of PlSe and WBGPx with persistent wheeze showed significant inverse trends (P = 0.005 for both), but these reduced after adjustment. Conclusions and Clinical Relevance Our results do not support a strong association between selenium status and the high incidence of asthma in New Zealand. However, there was a modest association between lower PlSe and WBGPx activity and higher incidence of persistent wheeze. Citing Literature Volume42, Issue4April 2012Pages 560-567 RelatedInformation
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