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Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer

1999; Springer Nature; Volume: 80; Issue: 12 Linguagem: Inglês

10.1038/sj.bjc.6690630

1532-1827

D. Gwyn Bebb, Zonggang Yu, Jinxin Chen, Milhan Telatar, Karen A. Gelmon, N. Phillips, Richard A. Gatti, Barry W. Glickman,

Genetic factors in colorectal cancer

Epidemiological evidence points to an increased risk of breast cancer in ataxia telangiectasia (AT) heterozygote women. Previous attempts to screen early onset or familial breast cancer patients failed to confirm an association. The issue of AT and late onset sporadic breast cancer remained unresolved. We screened 47 women who developed later onset, sporadic breast cancer for ataxia telangiectasia mutated (ATM) mutations. No mutations were found.