Artigo Revisado por pares

Chemometric approach to a QSAR study of peptides behaving as NK-2 receptor antagonists

1990; Elsevier BV; Volume: 3; Issue: 6 Linguagem: Inglês

10.1016/0898-5529(90)90065-g

ISSN

1878-335X

Autores

Sérgio Clementi, Gabriele Cruciani, Daniela Riganelli, Paolo Rovero, Vittorio Pestellini, Carlo Alberto Maggi, Massimo Baroni,

Tópico(s)

Analytical Chemistry and Chromatography

Resumo

This paper shows the advantages of using chemometric strategies in QSAR of NKA analogues containing D-Tryptophan and behaving as highly selective NK-2 receptor antagonists: a) detecting the sequence with optimal antagonist activity, and b) having a strategy for selecting a few most informative sequences. The data set is included on disk as RVD .DAT.

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