DEMENTIA PRECOX AS AN ENDOCRINOPATHY WITH CLINICAL AND AUTOPSY REPORTS*
1929; Oxford University Press; Volume: 13; Issue: 1 Linguagem: Inglês
10.1210/endo-13-1-73
ISSN1945-7170
Autores Tópico(s)Diet and metabolism studies
ResumoThe literature contains many references to the changes of the endocrine glands in dementia precox. Kraepelin (1) in 1881 first called attention to the relation of this disease to the endocrines, especially to the sex glands. Dercum (2) postulates that in dementia precox the various glands of internal secretion have suffered in the course of the development of the organism so that their respective functions are subsequently imperfectly and aberrantly performed. He feels that it is not at all unlikely that, while a number of glands, perhaps the entire chain, are involved in most cases, e.g., the gonads may dominate the picture, in others again it is the thymus; in still others it is the system of the pituitary, thyroid and adrenals. He regards the thymus as most likely to be involved because cases of dementia precox frequently betray in childhood the forerunners of the affection. From the histological study of two cases Kojima (3) concludes that the thyroids have an opposite appearance in the male and female; a tendency to hypofunction in the male and hyperfunction in the female. He states that in dementia precox the glands, on the whole, are small, especially in the female.
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