Experience with Intraperitoneal Alpha-2a Interferon
1992; Karger Publishers; Volume: 49; Issue: 6 Linguagem: Inglês
10.1159/000227094
ISSN1423-0232
AutoresOrnella Nicoletto, Mario V. Fiorentino, Orazio Vinante, Angelo Prosperi, F Tredese, Salvatore Tumolo, Giovanni P. Cima, S. Monfardini,
Tópico(s)Eosinophilic Disorders and Syndromes
ResumoEighteen patients affected with epithelial ovarian cancer have been treated by intraperitoneal α2a-Interferon. The usual single dosage was 54 x 106 U at weekly intervals for four times (eight times in responders): 10 h-istologically confirmed complete remissions and 3 partial remissions have been obtained; the toxicity was represented by fever in the majority of the cases, by abdominal discomfort in some cases, and by a mild transitory neurological complication in 1 case. Seventeen of 18 patients were pretreated, and 11 of 18 had only cytologic and/or microscopic disease. α2a-Interferon has proven to be very effective and moderately toxic in microscopic peritoneal disease of ovarian epithelial cancer previously treated with extensive surgery and intravenous cytotoxic chemotherapy.
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