Effects of crude herbal ingredients on serum levels of inflammatory cytokines in a rat uterine endometritis model
2000; Elsevier BV; Volume: 60; Issue: 2 Linguagem: Inglês
10.1016/s0011-393x(00)88485-4
ISSN1879-0313
AutoresHiroshige Mikamo, Kyoko Kawazoe, Yasumasa Sato, Yoh Hayasaki, Koji Izumi, Teruhiko Tamaya,
Tópico(s)Dermatology and Skin Diseases
ResumoThe effects of crude herbal ingredients that constitute Juzen-taihoto and Ryutan-shakan-to on serum levels of inflammatory cytokines in a rat uterine endometritis model were investigated. Extracts of Glycyrrhizae Radix, Cnidii Rhizoma, Rehmanniae Radix, Alismatis Rhizoma, Cinnamomi Cortex, Hoelen, and Angelicae Radix significantly inhibited serum levels of the inflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6. The decreased serum levels of inflammatory cytokines appeared to support a previous report on decreased uterine bacterial counts in the rat uterine endometritis model. Based on these results, it is thus speculated that herbal medicines might enhance the host-defense mechanism by decreasing the production of inflammatory cytokines.
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