Effect of endothelin-1, endothelin-3 and C-terminal hexapeptide, endothelin (16–21) on motor activity in rats
1990; Elsevier BV; Volume: 16; Issue: 1 Linguagem: Inglês
10.1016/0143-4179(90)90025-t
ISSN1532-2785
AutoresAlessandro Lecci, C.A. Maggi, Paolo Rovero, Antonio Giachetti, Alberto Meli,
Tópico(s)Renin-Angiotensin System Studies
ResumoIntracerebroventricular administration of ET-1 (12.5 and 25 pmol/rat) and ET-3 (25 and 50 pmol/rat) induced the loss of the righting reflex and barrel-rolling behaviour in rats. The C-terminal hexapeptide ET(16–21) did not produce these effects. The automated recording of motor activity revealed that, unlike ET(16–21), both ET-1 and ET-3 evoke a dose-regulated increase of the immobility time. Pretreatment with peptidase inhibitors did not modify the activity of subthreshold doses of peptides. Since ET(16–21) displays full agonist properties at ETb but does not interact with ETa receptors, the present data suggest that the behavioural syndrome induced by centrally administered ET-1 and ET-3 may be mediated by stimulation of ETa receptors.
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