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Maternal dietary n-3 fatty acids alter immune cell fatty acid composition and leukotriene production in growing chicks

2006; Elsevier BV; Volume: 76; Issue: 1 Linguagem: Inglês

10.1016/j.plefa.2006.09.003

1532-2823

Jean A. Hall, Shivesh Jha, Monica M. Skinner, Gita Cherian,

Peroxisome Proliferator-Activated Receptors

Summary The effect of feeding different amounts of n-6 and n-3 fatty acids (FA) to hens on immune tissue FA composition and leukotriene production of hatched chicks was investigated. Hens were fed diets supplemented with either 3.0% sunflower oil (Diet I), 1.5% sunflower+1.5% fish oil (Diet II), or 3.0% fish oil (Diet III) for 46 days. The hatched chicks were fed a diet containing C18:3n-3, but devoid of longer chain n-6 and n-3 FA, for 21 days. Spleen docosahexaenoic acid (DHA) content was higher in chicks from hens fed Diet III ( P <0.05). The bursa content of arachidonic acid was lower in chicks hatched from hens fed Diet III ( P <0.05), and the ratio of n-6 to n-3 FA was significantly higher in bursa of chicks hatched to hens fed Diet I ( P <0.05). Eicosapentaenoic acid (EPA) and DHA contents were higher in bursa of chicks hatched from hens fed Diet III ( P <0.05). Thrombocytes from chicks hatched to hens fed Diet III produced the most leukotriene B 5 (LTB 5 ). The ratio of LTB 5 to LTB 4 concentrations was also highest ( P <0.05) in chicks hatched to hens fed Diet III. These results indicate that modulating maternal dietary n-6 and n-3 FA may alter leukotriene production in chicks, which could lead to less inflammatory-related disorders in poultry.