Portal de Periódicos da CAPES

Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger

1992; Royal Society; Volume: 250; Issue: 1328 Linguagem: Inglês

10.1098/rspb.1992.0139

1471-2954

A. A. Selyanko, Catherine E. Stansfeld, David A. Brown,

Neuroscience and Neuropharmacology Research

Restricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Selyanko A. A. , Stansfeld C. E. and Brown David Anthony 1992Closure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messengerProc. R. Soc. Lond. B.250119–125http://doi.org/10.1098/rspb.1992.0139SectionRestricted accessArticleClosure of potassium M-channels by muscarinic acetylcholine-receptor stimulants requires a diffusible messenger A. A. Selyanko Google Scholar Find this author on PubMed Search for more papers by this author , C. E. Stansfeld Google Scholar Find this author on PubMed Search for more papers by this author and David Anthony Brown Google Scholar Find this author on PubMed Search for more papers by this author A. A. Selyanko Google Scholar Find this author on PubMed , C. E. Stansfeld Google Scholar Find this author on PubMed and David Anthony Brown Google Scholar Find this author on PubMed Published:23 November 1992https://doi.org/10.1098/rspb.1992.0139AbstractThe M-current (IK(M)) is a slow voltage-gated K+ current which can be inhibited by muscarinic acetylcholine-receptor (mAChR) agonists. In the present experiments we have tested whether this inhibition results from a local (membrane-delimited) interaction between the receptor and adjacent channels, or whether channel closure is mediated by a diffusible messenger. To do this, single Km+-channel currents were recorded from membrane patches in dissociated rat superior cervical sympathetic neurons by using cell-attached patch electrodes. Channel activity was inhibited when muscarine was applied to the cell membrane outside the patch but persisted when channels were exposed to muscarine added to the pipette solution. We conclude that a diffusible molecule (or molecules) is (are) required to induce intrapatch channel closure following activation of extra-patch receptors.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. Previous ArticleNext Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsCited by Ramakrishna Y, Manca M, Glowatzki E and Sadeghi S (2021) Cholinergic Modulation of Membrane Properties of Calyx Terminals in the Vestibular Periphery, Neuroscience, 10.1016/j.neuroscience.2020.10.035, 452, (98-110), Online publication date: 1-Jan-2021. Brown D (2020) Neurons, Receptors, and Channels, Annual Review of Pharmacology and Toxicology, 10.1146/annurev-pharmtox-010919-023755, 60:1, (9-30), Online publication date: 6-Jan-2020. Brown D (2018) Regulation of neural ion channels by muscarinic receptors, Neuropharmacology, 10.1016/j.neuropharm.2017.11.024, 136, (383-400), Online publication date: 1-Jul-2018. Puente E, De la Cruz L, Arenas I, Elias-Viñas D and Garcia D (2016) Voltage-Independent Inhibition of the Tetrodotoxin-Sensitive Sodium Currents by Oxotremorine and Angiotensin II in Rat Sympathetic Neurons, Molecular Pharmacology, 10.1124/mol.115.101931, 89:4, (476-483), Online publication date: 1-Apr-2016. He L, Zhang Q, Wang L, Dai J, Wang C, Zheng L and Zhou Z (2015) Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells, Philosophical Transactions of the Royal Society B: Biological Sciences, 370:1672, Online publication date: 5-Jul-2015. Gamper N and Rohacs T (2012) Phosphoinositide Sensitivity of Ion Channels, a Functional Perspective Phosphoinositides II: The Diverse Biological Functions, 10.1007/978-94-007-3015-1_10, (289-333), . Brown D and Passmore G (2009) Neural KCNQ (Kv7) channels, British Journal of Pharmacology, 10.1111/j.1476-5381.2009.00111.x, 156:8, (1185-1195) Gribkoff V (2008) The therapeutic potential of neuronal K V 7 (KCNQ) channel modulators: an update , Expert Opinion on Therapeutic Targets, 10.1517/14728222.12.5.565, 12:5, (565-581), Online publication date: 1-May-2008. Brown D (2007) The Skok legacy and beyond: Molecular mechanisms of slow synaptic excitation in sympathetic ganglia, Neurophysiology, 10.1007/s11062-007-0033-6, 39:4-5, (243-247), Online publication date: 1-Jul-2007. Gamper N and Shapiro M (2007) Target-specific PIP 2 signalling: how might it work? , The Journal of Physiology, 10.1113/jphysiol.2007.132787, 582:3, (967-975), Online publication date: 1-Aug-2007. Brown D, Hughes S, Marsh S and Tinker A (2007) Regulation of M(Kv7.2/7.3) channels in neurons by PIP 2 and products of PIP 2 hydrolysis: significance for receptor-mediated inhibition , The Journal of Physiology, 10.1113/jphysiol.2007.132498, 582:3, (917-925), Online publication date: 1-Aug-2007. Gamper N, Stockand J and Shapiro M (2005) The use of Chinese hamster ovary (CHO) cells in the study of ion channels, Journal of Pharmacological and Toxicological Methods, 10.1016/j.vascn.2004.08.008, 51:3, (177-185), Online publication date: 1-May-2005. Delmas P and Brown D (2005) Pathways modulating neural KCNQ/M (Kv7) potassium channels, Nature Reviews Neuroscience, 10.1038/nrn1785, 6:11, (850-862), Online publication date: 1-Nov-2005. Cho H, Kim Y, Yoon J, Lee D, Kim J, Lee S and Ho W (2005) Low mobility of phosphatidylinositol 4,5-bisphosphate underlies receptor specificity of Gq-mediated ion channel regulation in atrial myocytes, Proceedings of the National Academy of Sciences, 10.1073/pnas.0408851102, 102:42, (15241-15246), Online publication date: 18-Oct-2005. Shapiro M (2004) Why Biophysicists Make Models, Journal of General Physiology, 10.1085/jgp.200409095, 123:6, (657-662), Online publication date: 1-Jun-2004. Zhang H, Craciun L, Mirshahi T, Rohács T, Lopes C, Jin T and Logothetis D (2003) PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents, Neuron, 10.1016/S0896-6273(03)00125-9, 37:6, (963-975), Online publication date: 1-Mar-2003. Hoshi N, Zhang J, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N, Langeberg L, Yoneda Y, Scott J, Brown D and Higashida H (2003) AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists, Nature Neuroscience, 10.1038/nn1062, 6:6, (564-571), Online publication date: 1-Jun-2003. Gamper N and Shapiro M (2003) Calmodulin Mediates Ca2+-dependent Modulation of M-type K+ Channels, Journal of General Physiology, 10.1085/jgp.200208783, 122:1, (17-31), Online publication date: 1-Jul-2003. Roche J, Westenbroek R, Sorom A, Hille B, Mackie K and Shapiro M (2009) Antibodies and a cysteine-modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K + channels , British Journal of Pharmacology, 10.1038/sj.bjp.0704989, 137:8, (1173-1186), Online publication date: 1-Dec-2002. Suh B and Hille B (2002) Recovery from Muscarinic Modulation of M Current Channels Requires Phosphatidylinositol 4,5-Bisphosphate Synthesis, Neuron, 10.1016/S0896-6273(02)00790-0, 35:3, (507-520), Online publication date: 1-Aug-2002. Ikeda S and Kammermeier P (2002) M Current Mystery Messenger Revealed?, Neuron, 10.1016/S0896-6273(02)00792-4, 35:3, (411-412), Online publication date: 1-Aug-2002. Chen H, Kurennyi D and Smith P (2001) Modulation of M-channel conductance by adenosine 5' triphosphate in bullfrog sympathetic B-neurones, Journal of Autonomic Pharmacology, 10.1046/j.1365-2680.2001.00208.x, 21:1, (57-62), Online publication date: 1-Feb-2001. Selyanko A, Hadley J and Brown D (2001) Properties of single M‐type KCNQ2/KCNQ3 potassium channels expressed in mammalian cells, The Journal of Physiology, 10.1111/j.1469-7793.2001.00015.x, 534:1, (15-24), Online publication date: 1-Jul-2001. Brown B and Yu S (2000) Modulation and genetic identification of the M channel, Progress in Biophysics and Molecular Biology, 10.1016/S0079-6107(00)00004-3, 73:2-4, (135-166), Online publication date: 1-Feb-2000. Schwake M, Pusch M, Kharkovets T and Jentsch T (2000) Surface Expression and Single Channel Properties of KCNQ2/KCNQ3, M-type K+ Channels Involved in Epilepsy, Journal of Biological Chemistry, 10.1074/jbc.275.18.13343, 275:18, (13343-13348), Online publication date: 1-May-2000. Selyanko A, Hadley J, Wood I, Abogadie F, Jentsch T and Brown D (2000) Inhibition of KCNQ1‐4 potassium channels expressed in mammalian cells via M 1 muscarinic acetylcholine receptors , The Journal of Physiology, 10.1111/j.1469-7793.2000.t01-2-00349.x, 522:3, (349-355), Online publication date: 1-Feb-2000. Brown D (2000) M-Current: From Discovery to Single Channel Currents Slow Synaptic Responses and Modulation, 10.1007/978-4-431-66973-9_2, (15-26), . Río E, Bevilacqua J, Marsh S, Halley P and Caulfield M (2004) Muscarinic M 1 receptors activate phosphoinositide turnover and Ca 2+ mobilisation in rat sympathetic neurones, but this signalling pathway does not mediate M‐current inhibition , The Journal of Physiology, 10.1111/j.1469-7793.1999.00101.x, 520:1, (101-111), Online publication date: 1-Oct-1999. Bowden S, Selyanko A and Robbins J (2004) The role of ryanodine receptors in the cyclic ADP ribose modulation of the M‐like current in rodent m1 muscarinic receptor‐transformed NG108‐15 cells, The Journal of Physiology, 10.1111/j.1469-7793.1999.0023o.x, 519:1, (23-34), Online publication date: 1-Aug-1999. Conley E (1999) VLG K M-i [native] Ion Channel Factsbook, 10.1016/B978-012184453-0/50016-0, (657-702), . Lamas J (1999) The role of calcium in M-current inhibition by muscarinic agonists in rat sympathetic neurons, NeuroReport, 10.1097/00001756-199908020-00032, 10:11, (2395-2400), Online publication date: 1-Aug-1999. Selyanko A and Sim J (2004) Ca 2+ -inhibited non-inactivating K + channels in cultured rat hippocampal pyramidal neurones , The Journal of Physiology, 10.1111/j.1469-7793.1998.071bz.x, 510:1, (71-91), Online publication date: 1-Jul-1998. Delmas P, Abogadie F, Dayrell M, Haley J, Milligan G, Caulfield M, Brown D and Buckley N (2001) G-proteins and G-protein subunits mediating cholinergic inhibition of N-type calcium currents in sympathetic neurons, European Journal of Neuroscience, 10.1046/j.1460-9568.1998.00170.x, 10:5, (1654-1666), Online publication date: 1-May-1998. Villarroel A (1997) Nonstationary Noise Analysis of M Currents Simulated and Recorded in PC12 Cells, Journal of Neurophysiology, 10.1152/jn.1997.77.4.2131, 77:4, (2131-2138), Online publication date: 1-Apr-1997. Marrion N (1997) CONTROL OF M-CURRENT, Annual Review of Physiology, 10.1146/annurev.physiol.59.1.483, 59:1, (483-504), Online publication date: 1-Oct-1997. Lamas J, Selyanko A and Brown D (2006) Effects of a Cognition-enhancer, Linopirdine (DuP 996), on M-type Potassium Currents (I K(M) ) Some Other Voltage- and Ligand-gated Membrane Currents in Rat Sympathetic Neurons , European Journal of Neuroscience, 10.1111/j.1460-9568.1997.tb01637.x, 9:3, (605-616), Online publication date: 1-Mar-1997. Kurennyi D, Chen H and Smith P (1997) Low concentrations of muscarine potentiate M-current in bullfrog sympathetic B-neurones, Journal of the Autonomic Nervous System, 10.1016/S0165-1838(97)00103-3, 67:1-2, (89-96), Online publication date: 1-Dec-1997. SELYANKO A and BROWN D (1996) Regulation of M-type Potassium Channels in Mammalian Sympathetic Neurons: Action of Intracellular Calcium on Single Channel Currents, Neuropharmacology, 10.1016/0028-3908(96)00135-9, 35:7, (933-947), . Marrion N (1996) Calcineurin Regulates M Channel Modal Gating in Sympathetic Neurons, Neuron, 10.1016/S0896-6273(00)80033-1, 16:1, (163-173), Online publication date: 1-Jan-1996. Selyanko A and Brown D (1996) Intracellular Calcium Directly Inhibits Potassium M Channels in Excised Membrane Patches from Rat Sympathetic Neurons, Neuron, 10.1016/S0896-6273(00)80032-X, 16:1, (151-162), Online publication date: 1-Jan-1996. Minota S (1995) Delayed onset and slow time course of the non-M-type muscarinic current in bullfrog sympathetic neurons, Pfl�gers Archiv European Journal of Physiology, 10.1007/BF00704163, 429:4, (570-577), Online publication date: 1-Feb-1995. Chen H, Jassar B, Kurenny D and Smith P (2012) Phorbol ester-induced M-current suppression in bull-frog sympathetic ganglion cells: insensitivity to kinase inhibitors, British Journal of Pharmacology, 10.1111/j.1476-5381.1994.tb16173.x, 113:1, (55-62), Online publication date: 1-Sep-1994. Nakajima Y and Nakajima S (1994) Signal Transduction Mechanisms of Tachykinin Effects on Ion Channels The Tachykinin Receptors, 10.1007/978-1-4612-0301-8_11, (285-327), . BROWN D, HIGASHIDA H, NODA M, ISHIZAKA N, HASHII M, HOSHI N, YOKOYAMA S, FUKUDA K, KATAYAMA M, NUKADA T, KAMEYAMA K, ROBBINS J, MARSH S and SELYANKO A (1993) Coupling of Muscarinic Receptor Subtypes to Ion Channels: Experiments on Neuroblastoma Hybrid Cells, Annals of the New York Academy of Sciences, 10.1111/j.1749-6632.1993.tb38056.x, 707:1 Molecular Bas, (237-258), Online publication date: 1-Dec-1993. Revill A, Katzell A, Del Negro C, Milsom W and Funk G (2021) KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-Bötzinger Complex of Neonatal Rats in vitro, Frontiers in Physiology, 10.3389/fphys.2021.626470, 12 This Issue23 November 1992Volume 250Issue 1328 Article InformationDOI:https://doi.org/10.1098/rspb.1992.0139PubMed:1361985Published by:Royal SocietyPrint ISSN:0962-8452Online ISSN:1471-2954History: Manuscript received27/07/1992Manuscript accepted10/08/1992Published online01/01/1997Published in print23/11/1992 License:Scanned images copyright © 2017, Royal Society Citations and impact Large datasets are available through Proceedings B's partnership with Dryad