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Recent observations on the proximal tubular transport of acidic and basic amino acids by rat renal proximal tubular brush border vesicles

1980; Elsevier BV; Volume: 12; Issue: 1-2 Linguagem: Inglês

10.1016/0020-711x(80)90074-9

1878-6014

Heini Murer, Anja Leopolder, Rolf K. H. Kinne, Gerhard Burckhardt,

Metabolism and Genetic Disorders

1. Transport of l-glutamic acid by rat renal brush border membrane vesicles is sodium-dependent. 2. Present at the inner membrane surface potassium stimulates sodium-dependent L-glutamic acid uptake. 3. Sodium stimulated l-glutamic acid uptake is potential-sensitive only in the presence of potassium. 4. Transport of l-ornithine can also be stimulated by a sodium gradient. 5. However, in the absence of sodium, l-ornithine seems to cross the membrane by facilitated diffusion.