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Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches

1998; American Association for the Advancement of Science; Volume: 280; Issue: 5361 Linguagem: Inglês

10.1126/science.280.5361.275

1095-9203

Hisashi Saitō, Yutaka Kanamori, Toshitada Takemori, Hideo Nariuchi, Eiro Kubota, Hiromi Takahashi‐Iwanaga, Toshihiko Iwanaga, Hiromichi Ishikawa,

HIV Research and Treatment

Cryptopatches (CPs) are part of the murine intestinal immune compartment. Cells isolated from CPs of the small intestine that were c-kit positive (c-kit + ) but lineage markers negative (Lin − ) gave rise to T cell receptor (TCR) αβ and TCR γδ intestinal intraepithelial T cells after in vivo transfer or tissue engraftment into severe combined immunodeficient mice. In contrast, cells from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit + Lin − cells, failed to do so. These findings and results of electron microscopic analysis provide evidence of a local intestinal T cell precursor that develops in the CPs.