Meta-Analysis of Randomized Clinical Trials of Finasteride
1998; Elsevier BV; Volume: 51; Issue: 4 Linguagem: Inglês
10.1016/s0090-4295(98)00055-7
ISSN1527-9995
Autores Tópico(s)Hormonal and reproductive studies
ResumoA meta-analysis was recently published based on six randomized clinical trials of at least one year duration involving finasteride 5 mg and placebo in the treatment of men with clinical benign prostatic hyperplasia (BPH). In a pooled analysis, mean improvement in symptoms and urinary flow rate with finasteride were found to increase with increasing prostate size. This article reviews the previous publication of this meta-analysis, which indicated prostate volume is a key predictor of outcomes with finasteride treatment and suggested that finasteride is most effective in men with large prostates.
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