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Vaccination against Taenia solium cysticercosis in underfed rustic pigs of México: roles of age, genetic background and antibody response

2000; Elsevier BV; Volume: 90; Issue: 3 Linguagem: Inglês

10.1016/s0304-4017(00)00233-8

1873-2550

Mario M. Carrillo Huerta, Edda Sciutto, G. Garcia, Nelly Villalobos, M. Hernández, Gladis Fragoso, Julio Díaz, A. Dı́az, Ramsés E. Ramírez, Susana de la Luna, José L. Garcı́a, Edenil Costa Aguilar, Surizaray G. Espinoza, G Castilla, Juan R. Bobadilla, Ricardo Andrez Machado‐de‐Ávila, Marco V. José, C. Larralde, Aline S. de Aluja,

Toxoplasma gondii Research Studies

Vaccination of pigs of mixed genetic make-up, raised as rustically as done in rural Mexico, resulted in effective protection to experimental challenge against Taenia solium cysticercosis. Maximum protection was achieved if pigs were immunized at 70 days of age. There was large variation of viable parasite load within vaccinated pigs and controls, which is suggestive of significant genetic factors influencing susceptibility, besides immunization. Our results strengthen the advisability of pig vaccination for control of T. solium cysticercosis, since it lowers the number of viable cysticerci capable of transforming into tapeworms.