Synthesis of 188Re-MDP complex using carrier-free 188Re
1996; Elsevier BV; Volume: 47; Issue: 2 Linguagem: Inglês
10.1016/0969-8043(95)00281-2
ISSN1872-9800
AutoresKazuyuki Hashimoto, Sri Bagiawati, Mishiroku IZUMO, Katsutoshi Kobayashi,
Tópico(s)Neuroendocrine Tumor Research Advances
ResumoThe synthesis of a rhenium-MDP labelled compound using carrier-free 188Re from the 188W/188Re generator was investigated. Stannous chloride was used as the reducing agent for the reduction of rhenium. Dependence of the yield of Re-MDP upon the concentration of reducing agent, reaction time, antioxidant, pH, temperature, ionic strength and adding the carrier was examined. Under optimum conditions, the yields of Re-MDP were 85–89% using carrier-free 188Re and 92–95% using carrier-added 188Re. Furthermore, the stability of Re-MDP at different pHs was studied.
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