Produção Nacional
Revisado por pares
Polymorphisms in Inflammasome' Genes and Susceptibility to HIV-1 Infection
2012; Lippincott Williams & Wilkins; Volume: 59; Issue: 2 Linguagem: Inglês
10.1097/qai.0b013e3182392ebe
ISSN1944-7884
AutoresAlessandra Pontillo, Telma Miyuki Oshiro, Martina Girardelli, Anselmo Jiro Kamada, Sérgio Crovella, Alberto J. S. Duarte,
Tópico(s)Immune Cell Function and Interaction
ResumoThe involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.
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