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One-Pot Multistep Synthetic Strategies for the Production of Fenpropimorph Using an Ionic Liquid Solvent

2005; American Chemical Society; Volume: 10; Issue: 1 Linguagem: Inglês

10.1021/op050172m

1520-586X

Stewart A. Forsyth, H. Q. Nimal Gunaratne, Christopher Hardacre, Angela McKeown, David W. Rooney,

Catalytic Cross-Coupling Reactions

The one-pot synthesis of the fungicide fenpropimorph has been achieved using two different synthetic strategies in an ionic liquid. The first pathway consists of a Heck coupling followed by reductive amination; the second pathway consists of an aldol condensation followed by hydrogenation/reductive amination. Homogeneous and heterogeneous palladium catalysts have been utilised in the ionic liquid to provide a catalyst/solvent system that is suitable for recycling and process optimisation.