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The rainbow trout genome provides novel insights into evolution after whole-genome duplication in vertebrates

2014; Nature Portfolio; Volume: 5; Issue: 1 Linguagem: Inglês

10.1038/ncomms4657

2041-1723

Camille Berthelot, Frédéric Brunet, Domitille Chalopin, Amélie Juanchich, Maria Bernard, Benjamin Noël, Pascal Bento, Corinne Da Silva, Karine Labadie, Adriana Alberti, Jean‐Marc Aury, Alexandra Louis, Patrice Déhais, Philippe Bardou, Jérôme Montfort, Christophe Klopp, Cédric Cabau, Christine Gaspin, Gary H. Thorgaard, Mekki Boussaha, Edwige Quillet, René Guyomard, Delphine Galiana-Arnoux, Julien Bobe, Jean‐Nicolas Volff, Carine Genêt, Patrick Wincker, Olivier Jaillon, Hugues Roest Crollius, Yann Guiguen,

CRISPR and Genetic Engineering

Vertebrate evolution has been shaped by several rounds of whole-genome duplications (WGDs) that are often suggested to be associated with adaptive radiations and evolutionary innovations. Due to an additional round of WGD, the rainbow trout genome offers a unique opportunity to investigate the early evolutionary fate of a duplicated vertebrate genome. Here we show that after 100 million years of evolution the two ancestral subgenomes have remained extremely collinear, despite the loss of half of the duplicated protein-coding genes, mostly through pseudogenization. In striking contrast is the fate of miRNA genes that have almost all been retained as duplicated copies. The slow and stepwise rediploidization process characterized here challenges the current hypothesis that WGD is followed by massive and rapid genomic reorganizations and gene deletions. Although whole-genome duplications (WGDs) are rare events, they have an important role in shaping vertebrate evolution. Here, the authors sequence the rainbow trout genome and show that rediploidization after WGD occurs in a slow and stepwise manner.