Metabolism of β-muricholic acid in man
1985; Elsevier BV; Volume: 45; Issue: 5 Linguagem: Inglês
10.1016/0039-128x(85)90006-6
ISSN1878-5867
AutoresE Sacquet, Michel Parquet, Michel Riottot, A Raizman, Bernard Nordlinger, R. Infante,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoLabeled β-muricholic acid was obtained from germfree rats given [24-14C]-chenodeoxycholic acid. It was crystallized with the same unlabeled bile acid extracted from germfree rat pooled biles. Five patients fitted with a T-tube after cholecystectomy were given orally 100 mg of the bile acid. Metabolites of β-muricholic acid in bile, urine and feces were studied. Glyco- and tauro-β-muricholic acid were the only metabolites detected in bile. The urinary bile acid pattern was complex and included free, glyco- and sulfoconjugated β-muricholic acid, but no glucuronide was observed. Analysis of fecal bile acid showed very few metabolites: the 3β-epimer was identified; the 6β- and 7β-hydroxyls were apparently not transformed by human intestinal microflora.
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