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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Garcinielliptone FC, a polyisoprenylated benzophenone from Platonia insignis Mart., promotes vasorelaxant effect on rat mesenteric artery

2014; Taylor & Francis; Volume: 28; Issue: 12 Linguagem: Inglês

10.1080/14786419.2014.889136

ISSN

1478-6427

Autores

Daniel Dias Rufino Arcanjo, Joaquim Soares da Costa-Júnior, Lucas Henrique Porfírio Moura, Alexandre de Barros Falcão Ferraz, Raíssa Rebés Rossatto, Jorge M. David, Lucindo José Quintans‐Júnior, Rita de Cássia Meneses Oliveira, Antônia Maria das Graças Lopes Citó, Aldeídia Pereira de Oliveira,

Tópico(s)

Biological and pharmacological studies of plants

Resumo

AbstractPolyisoprenylated benzophenones represent a group of chemical compounds commonly identified in Clusiaceae species and are responsible for a large amount of biological activities. In this work, the vasorelaxant effect induced by garcinielliptone FC (GFC) isolated from Platonia insignis Mart. (Clusiaceae), a monotype species from Platonia genus, was investigated. GFC promoted an endothelium-independent vasorelaxation on phenylephrine (PHE, 10− 5 mol L− 1)-induced vasoconstriction, but not on KCl (80 mmol L− 1)-induced vasoconstriction, on rat superior mesenteric artery rings. In addition, a concentration-dependent decrease of PHE- or serotonin-induced cumulative concentration–response curves was observed for GFC, and a slight decrease of pD2 value on CaCl2-induced vasoconstriction. In a Ca2+-free medium, GFC interfered in calcium mobilisation from PHE (10− 5 mol L− 1)-sensitive intracellular stores. GFC-induced vasorelaxant effect is probably mediated by a dual effect on mobilisation of calcium intracellular stores and attenuation of transmembrane calcium influx.Keywords:: benzophenonecalciumClusiaceaegarcinielliptonePlatoniavasorelaxant AcknowledgementsThis work was supported by UFPI (Federal University of Piauí, Brazil), FAPEPI (Fundação de Amparo à Pesquisa do Estado do Piauí, Brazil) and CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil).

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