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Solubility of Berberine Chloride in Various Solvents

2006; American Chemical Society; Volume: 51; Issue: 2 Linguagem: Inglês

10.1021/je0504360

1520-5134

Yangcheng Lü, Quan Lin, Guangsheng Luo, Dai Youyuan,

Thermodynamic properties of mixtures

The solubility of berberine chloride in ethanol, 2-propanol, 1-butanol, 1-octanol, ethanol + 2-propanol, ethanol + 1-butanol, and ethanol + 1-octanol was measured. According to the molecular structure of berberine chloride, we defined a new group [C5H2N+] based on the existing parameter table of UNIFAC (Dortmund) and derived the group parameters. The experimental solubility data were well correlated by the UNIFAC model. These newly defined groups and parameters could be expected to allow the prediction of the solubility of other isoquinoline alkaloids.