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Subthalamic stimulation activates internal pallidus: Evidence from cGMP microdialysis in PD patients

2005; Wiley; Volume: 57; Issue: 3 Linguagem: Inglês

10.1002/ana.20402

1531-8249

Alessandro Stefani, Ernesto Fedele, Salvatore Galati, Olimpia Pepicelli, Stefania Frasca, Mariangela Pierantozzi, Antonella Peppe, Livia Brusa, Antonio Orlacchio, Atticus H. Hainsworth, Giuseppe Gattoni, Paolo Stanzione, Giorgio Bernardi, Maurizio Raiteri, Paolo Mazzone,

Neuroscience and Neuropharmacology Research

Abstract Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN‐DBS. This supports the view that a clinically beneficial effect of STN‐DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi. Ann Neurol 2005;57:448–452