Structural and conformational study of 3,7-disubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones
1987; Elsevier BV; Volume: 156; Issue: 3-4 Linguagem: Inglês
10.1016/0022-2860(87)87027-8
ISSN1872-8014
AutoresM.S. Arias, Enrique J. Galvez, Juan‐Carlos Castillo, Juan J. Vaquero, Jesús Chicharro,
Tópico(s)Metal complexes synthesis and properties
Resumo3-Alkyl-7-methyl-3,7-diazabicyclo[3.3.1]nonan-9-ones have been studied by 1H- and 13C-NMR spectroscopy. In CDCl3 solutions, these ketones adopt a flattened chair—chair conformation with the N-substituents in the equatorial position. From the smallest (R = CH3) to the largest (R = CH(CH3)2) substituent, an increase of the distortion for the N-alkylated piperidone ring is observed.
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