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Sialic Acids and Related Substances

1963; Oxford University Press; Volume: 27; Issue: 1 Linguagem: Inglês

10.1271/bbb1961.27.60

1881-1280

Kônoshin Onodera, Eiichi Maekawa, Shôzaburo Kitaoka, Shigehiro Hirano,

Biochemical and Molecular Research

N-Acetyl-D-galactosamine, N-acetyl-D-mannosamine and N-acetyl-D-glucosamine were allowed to react with oxalacetic acid under alkaline conditions, and the condensation products purified by ion-exchange chromatography. Properties of these products on the whole are similar to each other, though there is a minor but significant difference in the condensation product with N-acetyl-D-galactosamine. Paper chromatograms of the condensation products suggest that N-acetyl-D-galactosamine as well as N-acetyl-D-glucosamine are epimerized partly before they condense with oxalacetic acid to give each two sialic acids with different configurations at C-5 from each other.