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Hypolipidaemic activity of methanol extract of Aleurites moluccana

2002; Wiley; Volume: 16; Issue: 8 Linguagem: Inglês

10.1002/ptr.1046

1099-1573

Rozangela Curi Pedrosa, Christiane Meyre‐Silva, Valdir Cechinel Filho, J. C. Benassi, Luís Flávio Souza de Oliveira, Vilmair Zancanaro, Jacir Dal Magro, Rosendo Augusto Yunes,

Phytochemistry and Biological Activities

The lipid-lowering action of the leaves of the Aleurites moluccana methanol extract was studied in Triton W-1339 and high-fat-diet fed rats. The serum lipids (total cholesterol, LDL- and HDL-cholesterol and triglycerides) and body weight were found to be lowered by A. moluccana (300 mg/kg, b.w.) in rats with Triton-induced hypercholesterolaemia and on a hyperlipaemic diet. The results suggest that the lipid lowering action of this natural product is mediated through inhibition of hepatic cholesterol biosynthesis and reduction of lipid absorption in the intestine.