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Prospective survey of digestive tract colonization with enterobacteriaceae that produce extended-spectrum β-lactamases in intensive care units

2005; Elsevier BV; Volume: 62; Issue: 3 Linguagem: Inglês

10.1016/j.jhin.2005.09.014

1532-2939

Geneviève Christiaens, Y. Ciccarella, Pierre Damas, Marie‐Pierre Hayette, Pierrette Melin, Monique Nys, Patrick De Mol,

Nosocomial Infections in ICU

Enterobacteriaceae that produce extended-spectrum β-lactamases (E-ESBLs) are an increasing problem. E-ESBLs are important agents of nosocomial infection and are responsible for outbreaks that occur predominantly in intensive care units (ICUs). 1 Pena C. Pujol M. Ardanuy C. et al. Epidemiology and successful control of a large outbreak due to K. pneumoniae producing extended-spectrum β-lactamases. Antimicrob Agents Chemother. 1998; 42: 53-58 PubMed Google Scholar ESBLs are most commonly produced by isolates of Klebsiella pneumoniae and Escherichia coli, but infection and colonization involving other ESBL-producing organisms such as Morganella morganii, Enterobacter spp., Citrobacter spp. and Proteus spp. have been reported. 2 Thomson K.S. Moland E.S. Version 2000: the new beta-lactamases of Gram-negative bacteria at the dawn of the new millennium. Microbes Infect. 2000; 2: 1225-1235 Crossref PubMed Scopus (90) Google Scholar In Belgium, over the last 15 years, nosocomial infections with E-ESBLs have gradually increased. ESBLs have mainly been studied from isolates of Enterobacter aerogenes, the species of greatest concern in Belgian hospitals. 3 De Gheldre Y. Glupczynski Y. Struelens M.J. et al. Emergence of E. aerogenes as a major antibiotic resistant nosocomial pathogen in Belgian hospitals. Clin Microbiol Infect. 1999; 5: 622-627 Crossref PubMed Scopus (26) Google Scholar