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Hemoglobinopathies Affect Hemoglobin A_1C Measurement

1991; American College of Physicians; Volume: 115; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-115-1-68_2

1539-3704

Gregory S. Holt,

Liver Disease Diagnosis and Treatment

Letters1 July 1991Hemoglobinopathies Affect Hemoglobin A1C MeasurementGregory S. Holt, MD, James L. Wofford, MD, Ramon Velez, MDGregory S. Holt, MDSearch for more papers by this author, James L. Wofford, MDSearch for more papers by this author, Ramon Velez, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-1-68_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Assays for hemoglobin (Hgb) A1Care considered by some to be the "gold standard" for monitoring long-term glycemic control in diabetic patients (1). Various techniques are currently available to measure Hgb A1C, including chromatography (column ion-exchange, liquid, affinity, minicolumn), electrophoresis (isoelectric focusing), and colorimetric methods. These methods have been shown to have reasonable precision. However, ion-exchange chromatography, a popular and relatively inexpensive technique, seems to be affected by hemoglobin variants (2). A falsely elevated Hgb A1Cby this method may occur in patients with increased Hgb F or beta-thalassemia, whereas falsely low results may occur when Hgb...References1. StrowigRaskin SP. Insulin treatment and patient management. In: Rifkin H, Porte D, eds. Diabetes Mellitus: Theory and Practice. 2d edition. New York: Elsevier; 1990:514-23. Google Scholar2. Eberentz-LhommeDucrocqIntratorElionNunezAssain CRSJER. Haemoglobinopathies: a pitfall in the assessment of glycosylated hemoglobin by ion-exchange chromatography. Diabetologia. 1984;27:596-8. CrossrefMedlineGoogle Scholar3. Beutler E. The sickle diseases and related disorders. In: Williams W, Beutler E, eds. Hematology. 4th edition. New York: McGraw-Hill; 1990:613-44. Google Scholar4. Ravel R. Tests for diabetes and hypoglycemia. In: Ravel R, ed. Clinical Laboratory Medicine. 5th edition. Chicago: Year Book Medical Publishers, Inc.; 1989:471-3. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bowman-Gray School of Medicine Reynolds Health Center Winston-Salem, NC 27103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEffect of Hemoglobinopathies on Hemoglobin A1c MeasurementsFetal Hemoglobin Alters Hemoglobin A1c MeasurementsRichard W. Bergstrom, MD, James R. Kelley, MD, W. Kenneth Ward, MD 1 July 1991Volume 115, Issue 1Page: 68-69KeywordsBeta-thalassemiaChromatographyHemoglobinHemoglobinopathies Issue Published: 1 July 1991 PDF DownloadLoading ...