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Four deaths and a funeral: from caspases to alternative mechanisms

2001; Nature Portfolio; Volume: 2; Issue: 8 Linguagem: Inglês

10.1038/35085008

1471-0080

Marcel Leist, Marja Jäättelä,

Calpain Protease Function and Regulation

A single family of proteases, the caspases, has long been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionarily conserved, caspase-independent controlled death mechanisms have opened new perspectives on the biology of cell demise, with particular implications for neurobiology, cancer research and immunological processes.