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Purification and properties of certain glutamic acid-metabolizing enzymes from cockroach-muscle mitochondria

1963; Elsevier BV; Volume: 73; Issue: 2 Linguagem: Inglês

10.1016/0926-6569(63)90154-8

1878-1454

Richard R. Mills, Donald G. Cochran,

Enzyme function and inhibition

Three glutamic acid-metabolizing enzymes have been identified and partially purified from cockroach thoracic muscle mitochondria. The enzymes are glutamic dehydrogenase, glutamic-aspartic transaminase and glutamic-alanine transaminase. The glutamic dehydrogenase appears to be NAD+ specific, while the two transaminases require pyridoxal phosphate. Substrate specificity, pH optima, and several other characteristics of each enzyme have been determined.