Portal de Periódicos da CAPES

Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León

2006; Arán Ediciones; Volume: 98; Issue: 12 Linguagem: Inglês

10.4321/s1130-01082006001200003

2340-4167

Alberto Muela Molinero, Francisco Jorquera, Toru Arino, R. Malagón Rojo, V. Espinel Díez, Beatriz Ballesteros del Río, J.L. Olcoz Goñi, J.A. Santos Calderón,

Metastasis and carcinoma case studies

Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León.Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002.A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed.Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives.The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first two years.No significative differences in survival were observed among patients with synchronous or metachronous MMPN.Conclusions: MMPN in patients with gastric neoplasms is a relevant problem.While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN.Secondary prevention is the best measure to avoid MMPN development.