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Clines with partial panmixia

2011; Elsevier BV; Volume: 81; Issue: 1 Linguagem: Inglês

10.1016/j.tpb.2011.09.006

1096-0325

Thomas Nagylaki,

Mathematical Biology Tumor Growth

In spatially distributed populations, global panmixia can be regarded as the limiting case of long-distance migration. The effect of incorporating partial panmixia into single-locus clines maintained by migration and selection is investigated. In a diallelic, two-deme model without dominance, partial panmixia can increase or decrease both the polymorphic area in the plane of the migration rates and the equilibrium gene-frequency difference between the two demes. For multiple alleles, under the assumptions that the number of demes is large and both migration and selection are arbitrary but weak, a system of integro-partial differential equations is derived. For two alleles with conservative migration, (i) a Lyapunov functional is found, suggesting generic global convergence of the gene frequency; (ii) conditions for the stability or instability of the fixation states, and hence for a protected polymorphism, are obtained; and (iii) a variational representation of the minimal selection-migration ratio λ(0) (the principal eigenvalue of the linearized system) for protection from loss is used to prove that λ(0) is an increasing function of the panmictic rate and to deduce the effect on λ(0) of changes in selection and migration. The unidimensional step-environment with uniform population density, homogeneous, isotropic migration, and no dominance is examined in detail: An explicit characteristic equation is derived for λ(0); bounds on λ(0) are established; and λ(0) is approximated in four limiting cases. An explicit formula is also deduced for the globally asymptotically stable cline in an unbounded habitat with a symmetric environment; partial panmixia maintains some polymorphism even as the distance from the center of the cline tends to infinity.