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Epidemiological and genetic study of 200 cases of oral cleft in the Emilia Romagna region of northern Italy

1988; Wiley; Volume: 38; Issue: 6 Linguagem: Inglês

10.1002/tera.1420380603

2472-1727

Elisa Calzolari, Mario Milan, G. B. Cavazzuti, G Cocchi, E. Gandini, Cinzia Magnani, Marcelo S. Moretti, Giampaolo Garani, G Salvioli, Stefano Volpato,

Craniofacial Disorders and Treatments

Abstract Epidemiological and genetic variables in clefts were analyzed during the years 1978–1986 in a case‐control study of congenital malformations in the Emilia Romagna region of northern Italy. Among 150,168 newborns, 200 cases of cleft were detected, yielding a prevalence of 1.33 per 1,000. These clefts consisted of 112 (0.075%) cases of cleft lip with or without cleft palate (CL±P) and 88 cases (0.058%) of cleft palate (CP). Coexisting abnormalities were found in 32% of cases. The heritability coefficient of CL±P was 0.84. No cluster in time or space could be demonstrated. Epilepsy was the only maternal risk factor found to be correlated with clefts. A predominance of males was found among CL±P cases.