The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade
2010; Springer Science+Business Media; Volume: 3; Issue: 1 Linguagem: Inglês
10.1007/s12307-010-0037-4
ISSN1875-2292
AutoresXiao-Feng Le, Omar Merchant, Robert C. Bast, George A. Calin,
Tópico(s)Cancer-related molecular mechanisms research
ResumoCancer metastasis results from a multi-step cascading process that includes: 1) vascularization of the primary tumor; 2) detachment and invasion of cancer cells; 3) intravasation into lymphatic and blood vessels; 4) survival and arrest in the circulation; 5) extravasation into distant organs; and 6) colonization and growth of metastatic tumors. microRNAs (miRNAs) play critical roles in this multi-step process, both promoting and suppressing metastasis. This review updates the progress made in understanding the roles of miRNAs for invasion and metastasis during cancer progression. A specific miRNA signature of cancer metastasis is also reviewed.
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