Portal de Periódicos da CAPES

Susceptibility Surveillance among Gram-Negative Bacilli at a Cancer Center

1999; Karger Publishers; Volume: 45; Issue: 5 Linguagem: Inglês

10.1159/000007223

1421-9794

Kalen Jacobson, Kenneth V. I. Rolston, Linda S. Elting, Barbara LeBlanc, Estella Whimbey, D H Ho,

Antibiotics Pharmacokinetics and Efficacy

We conducted a survey of susceptibility among 758 gram-negative bacilli (GNB; collected from cancer patients over a 3-month period) to commonly used antibiotics. The overall resistance among GNB was least for piperacillin/tazobactam and meropenem (5 and 6%, respectively) followed by cefepime (8%), imipenem (9%), amikacin (12%), ofloxacin (13%), ciprofloxacin, ceftazidime and ticarcillin/clavulanate (14% each), aztreonam (18%) and tobramycin (24%). In comparison to data on antibiotic resistance to ceftazidime, imipenem, ciprofloxacin and aztreonam in similar studies in 1985 and 1994, resistance has significantly increased to all four antibiotic classes. Based on our current study, meropenem, cefepime, imipenem and piperacillin/tazobactam would be the most appropriate choices in our institution for empiric therapy of GNB infections in febrile neutropenic patients.