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Electrochemical determination of oxytetracycline in veterinary drugs

2003; Elsevier BV; Volume: 34; Issue: 1 Linguagem: Inglês

10.1016/j.japna.2003.08.010

1873-264X

Marzanna Kurzawa, Agnieszka Kowalczyk-Marzec,

Analytical Chemistry and Chromatography

Conductometric, potentiometric and cyclic voltammetric (CV) titration methods are proposed for determination of oxytetracycline (OTC), commonly used in veterinary. The electrochemical titration of OTC hydrochloride with NH4Mo7O24, NaVO3, NaOH, AgNO3 and FeCl3 as titrants are reported. The proposed methods were found to be highly precise, having a relative standard deviation (R.S.D.) below 1.0%. Proposed electrochemical titrations were successfully applied to the assay of commercial preparations: Tetrox, Tetramutin®OT and Neox, containing the above-mentioned antibiotics. The validity of the methods was tested by the recovery studies of standard addition to pharmaceuticals and results were found to be satisfactory.