Immobilized benzylpenicillin acylase: Application to the synthesis of optically active forms of carnitin and propranalol
1986; Elsevier BV; Volume: 27; Issue: 18 Linguagem: Inglês
10.1016/s0040-4039(00)84449-4
ISSN1873-3581
AutoresClaudio Fuganti, Piero Grasselli, Pierfausto Seneci, Stefano De Servi, Paolo Casati,
Tópico(s)Biochemical and Molecular Research
ResumoThe hydrolysis at pH 7.5 in the presence of immobilized benzylpenicillin acylase of the N-phenacetyl derivatives of the primary amines (3)-(5) affords the hydroxy amines (6)-(8), key intermediates in the synthesis of optically active forms of carnitin and propranalol, of ca. 0.4, 0.3 and 0.8 ee, respectively.
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