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The telosome/shelterin complex and its functions

2008; Springer Science+Business Media; Volume: 9; Issue: 9 Linguagem: Inglês

10.1186/gb-2008-9-9-232

1465-6914

Huawei Xin, Dan Liu, Zhou Songyang,

DNA Repair Mechanisms

The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified - the telosome or shelterin complex - that is crucial for both the maintenance of telomere structure and its signaling functions.